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KMID : 0882420110800040419
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Korean Journal of Medicine
2011 Volume.80 No. 4 p.419 ~ p.426
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Prognostic Factors in Patients with Localized Soft Tissue Sarcoma
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Koh Sung-Ae
Lee Kyoung-Hee
Kim Min-Kyoung
Hyun Myung-Soo
Shin Duk-Seop
Yun Sang-Mo
Kang Min-Kyu
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Abstract
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Background/Aims : We evaluated the independent prognostic factors for overall and disease-free survival in the treatment of soft tissue sarcoma.
Methods: Sixty-seven medical records were retrospectively reviewed. All the patients had presented with localized soft tissue sarcoma and had been treated with conservative surgery, followed by additional therapy or surgery. All were treated at the Yeungnam University Hospital between January 2000 and December 2006. Univariate and multivariate analyses were used to evaluate factors affecting overall and disease-free survival.
Results: The median age of the study sample was 50 (range, 15~70) years. Twenty patients (30%) had liposarcoma and nine (13%) had leiomyosarcoma. Seventeen patients (25%) had a tumor measuring greater than 10 cm. Nineteen patients (28%) had positive resection margins. The median overall survival was 62.7 months (95% CI: 25.7~99.4) and the median disease-free survival was 36.1 months (95% CI: 17.9~54.2). Factors that significantly affected the median overall survival were a tumor size greater than 10 cm and performance status. Positive resection margins and tumor site were independent prognostic factors associated with disease- free survival. Other factors, such as histopathology, gender, age, and tumor grade, did not have prognostic value. Additionally, the chosen modality of treatment after surgery was not an independent predictor of the median overall or disease-free survival.
Conclusions: Tumor size, positive resection margins, tumor site, and performance status were statistically significant independent predictors of poor prognosis.
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KEYWORD
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Sarcoma, Disease-free survival, Retrospective study
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